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Methamphetamine Toxicities and Clinical Management

Published November 28, 2023
NEJM Evid 2023;2(12)
DOI: 10.1056/EVIDra2300160

Abstract

Methamphetamine use has increased over the past 15 years, with corresponding increases in associated morbidity and mortality. Toxicities from methamphetamine use largely consist of vascular and neuropsychiatric disorders, and are more likely to be due to long-term rather than acute exposure. The approach to managing methamphetamine use in clinical care settings has advanced recently, with universal diagnostic criteria for substance use disorders, promising data for several off-label pharmacotherapies, novel ideas for preventing and treating vascular and neuropsychiatric toxicities, and systematic prevention and screening for associated infectious and medical disorders among people who use substances. Here we review morbidity and mortality associated with methamphetamine use and discuss prevention and treatment strategies.

Notes

Disclosure forms provided by the authors are available with the full text of this article.

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Disclosure Forms (evidra2300160_disclosures.pdf)

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Editor

C. Corey Hardin, M.D., Ph.D., Editor

History

Published online: November 28, 2023
Published in issue: November 28, 2023

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Authors

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Phillip O. Coffin, M.D., M.I.A. [email protected]
Center on Substance Use and Health, San Francisco Department of Public Health, San Francisco
Department of Medicine, University of California San Francisco, San Francisco
Leslie W. Suen, M.D., M.A.S.
Department of Medicine, University of California San Francisco, San Francisco

Notes

Dr. Coffin can be contacted at [email protected] or at San Francisco Department of Public Health, 25 Van Ness Ave., Suite 500, San Francisco, CA 94102.

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